Each PLENVU ® treatment contains 491 mg of phenylalanine. PLENVU ® contains phenylalanine, a component of aspartame. Phenylalanine can be harmful to patients with phenylketonuria (PKU).Use PLENVU ® with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.Do not combine PLENVU ® with starch-based thickeners. Patients with impaired gag reflex or those prone to regurgitation or aspiration should be observed during the administration of PLENVU ®.Use caution in patients with severe ulcerative colitis. ![]() If GI obstruction or perforation is suspected, perform appropriate diagnostic studies prior to administering PLENVU ®. Do not administer PLENVU ® to patients with GI obstruction or perforation.Advise these patients to adequately hydrate before, during, and after the use of PLENVU ® and consider performing laboratory tests in these patients. Use PLENVU ® with caution in patients with renal impairment or those taking concomitant medications that affect renal function.Use PLENVU ® with caution in patients with a history of seizures and those at an increased risk of seizures, including patients taking medications that lower the seizure threshold, patients withdrawing from alcohol or benzodiazepines, or patients with hyponatremia.Consider obtaining ECGs in patients at an increased risk of serious cardiac arrhythmias. These occur predominantly in patients with underlying cardiac risk factors and electrolyte disturbances. There have been rare reports of serious arrhythmias associated with the use of ionic osmotic laxative products for bowel preparation.Fluid and electrolyte disturbances can lead to serious adverse events including cardiac arrhythmias, seizures, and renal impairment. It is encouraged that patients drink additional clear liquids to help avoid cases of fluid and electrolyte abnormalities. Advise patients to hydrate adequately before, during, and after the use of PLENVU ®. ![]()
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